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Bessen Lab

eagle-i ID

http://montana.eagle-i.net/i/0000012b-00bf-4604-df3b-3fdc80000000

Resource Type

  1. Laboratory

Properties

  1. Resource Description
    My laboratory is investigating agent-host interactions in prion diseases, which are fatal neurodegenerative diseases. These are important diseases of humans (Creutzfeldt-Jakob disease), livestock (e.g., scrapie in sheep and bovine spongiform encephalopathy in cattle) and cervids (chronic wasting disease) that have zoonotic potential. Although the majority of prion diseases are due to infection with the prion agent, they can also occur sporadically or as a result of an autosomal dominant mutation in the prion protein gene. The prion agent appears to be devoid of a nucleic acid genome and consists of a misfolded host protein, called PrP-res, that can further induce its own formation from the normal host prion protein. The multiple etiologies of prion diseases and the unusual nature of the infectious agent is novel in microbiology. Research projects in the Bessen lab include investigations of (1) the routes of prion neuroinvasion following oral exposure; (2) the mechanism of prion agent entry and spread in nerve cells and skeletal muscle; (3) the host physiological responses during chronic wasting disease infection; and (4) transgenic models of CWD pathogenesis. Currently, there are postdoctoral and technical positions as well as graduate student openings available in the laboratory to pursue these studies.
  2. Contact
    Bessen, Richard
  3. PI
    Bessen, Richard
  4. Affiliation
    Department of Microbiology and Immunology, Montana State University
  5. Performs Technique
    Experimental induction of disease
  6. Website(s)
    http://vmb.montana.edu/faculty/bessen/index.htm
  7. Website(s)
    http://www.mbprogram.montana.edu/faculty.asp?per_id=22&in_id=8
  8. Other members
    VanAntwerp, Dan
 
RDFRDF
 
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