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Suppression of TNF-alpha-induced apoptosis by NF-kappaB.

eagle-i ID

http://montana.eagle-i.net/i/0000012b-a80d-2a36-ae6b-6a4a80000000

Resource Type

  1. Journal article

Properties

  1. Resource Description
    Tumour necrosis factor (TNF) is an inflammatory cytokine possessing a unique property: it can induce cells to undergo apoptosis. The sensitivity of different cell types to TNF-induced apoptosis can vary dramatically, but most cells become very sensitive upon simultaneous treatment with inhibitors of protein synthesis. It has been suggested therefore that a gene, or set of genes, is induced upon TNF receptor activation that downregulates the apoptosis signal. Recent results have shown that NF-kappa B, a transcription factor activated upon TNF signalling, is at least partly responsible for this effect. These findings have broadened the role of NF-kappa B from that of a regulator of immune and inflammatory responses to include an involvement in the regulation of apoptosis.
  2. Website(s)
    http://www.ncbi.nlm.nih.gov/pubmed/9695819
  3. PubMed ID
    8864120
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    qking (Quinton King)
  3. created
    2010-10-13T19:05:11.417-05:00
  4. creator
    nvasilevsky
  5. modified
    2011-04-29T14:01:12.629-05:00

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