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FPR1 wild-type

eagle-i ID


Resource Type

  1. cDNA plasmid


  1. Construct Insert
    Human FPR1 wild-type
  2. Resource Description
    Human wild-type FPR1.
  3. Additional Name
    fMet-Leu-Phe receptor; Formyl peptide receptor 1
  4. Construct Backbone
  5. Accession Number
  6. Related Publication or Documentation
    Agonist-dependent phosphorylation of the formyl peptide receptor is regulated by the membrane proximal region of the cytoplasmic tail.
  7. Related Publication or Documentation
    Formyl peptide receptor-mediated ERK1/2 activation occurs through G(i) and is not dependent on beta-arrestin1/2.
  8. Related Publication or Documentation
    The ligand binding site of the formyl peptide receptor maps in the transmembrane region.
  9. Related Publication or Documentation
    Identification of putative sites of interaction between the human formyl peptide receptor and G protein.
  10. Related Publication or Documentation
    A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activation and chemotaxis.
  11. Related Publication or Documentation
    Activation and nuclear translocation of ERK1/2 by the formyl peptide receptor is regulated by G protein and is not dependent on beta-arrestin translocation or receptor endocytosis.
  12. Selectable Marker
  13. Related Technique
  14. Location
    Miettinen Lab
Provenance Metadata About This Resource Record
  1. workflow state
  2. contributor
  3. created
  4. creator
    qking (Quinton King)
  5. modified
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016