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eagle-i ID


Resource Type

  1. cDNA plasmid


  1. Construct Insert
    FPR1 D71A
  2. Resource Description
    Human FPR1 with D71A point mutation. Point mutations of human FPR1 cDNA clone R-26 were generated by oligonucleotide-directed mutagenesis and confirmed by DNA sequencing.
  3. Additional Name
    fMet-Leu-Phe receptor; Formyl peptide receptor 1
  4. Contact
    Miettinen, Heini
  5. Construct Backbone
  6. Accession Number
  7. Related Publication or Documentation
    The ligand binding site of the formyl peptide receptor maps in the transmembrane region.
  8. Related Publication or Documentation
    Identification of putative sites of interaction between the human formyl peptide receptor and G protein.
  9. Related Publication or Documentation
    A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activation and chemotaxis.
  10. Related Publication or Documentation
    Activation and nuclear translocation of ERK1/2 by the formyl peptide receptor is regulated by G protein and is not dependent on beta-arrestin translocation or receptor endocytosis.
  11. Selectable Marker
  12. Related Technique
  13. Location
    Miettinen Lab
Provenance Metadata About This Resource Record
  1. workflow state
  2. contributor
  3. created
  4. creator
    qking (Quinton King)
  5. modified

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016