FPR1 R123A

eagle-i ID

Resource Type

Properties

1. Construct Insert

   FPR1 R123A

2. Resource Description

   Human FPR1 with R123A point mutation. Point mutations of human FPR1 cDNA clone R-26 were generated by oligonucleotide-directed mutagenesis and confirmed by DNA sequencing.

3. Additional Name

   fMet-Leu-Phe receptor; Formyl peptide receptor 1

4. Contact

   Miettinen, Heini

5. Construct Backbone

   pBGSA

6. Accession Number

   M60627

7. Related Publication or Documentation

   Formyl peptide receptor-mediated ERK1/2 activation occurs through G(i) and is not dependent on beta-arrestin1/2.

8. Related Publication or Documentation

   Identification of putative sites of interaction between the human formyl peptide receptor and G protein.

9. Related Publication or Documentation

   Activation and nuclear translocation of ERK1/2 by the formyl peptide receptor is regulated by G protein and is not dependent on beta-arrestin translocation or receptor endocytosis.

10. Selectable Marker

    G418

11. Related Technique

    Transfection

12. Location

    Miettinen Lab