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FPR1 Y301A

eagle-i ID

http://montana.eagle-i.net/i/00000131-0095-e6b5-44b9-3efb80000000

Resource Type

  1. cDNA plasmid

Properties

  1. Construct Insert
    FPR1 Y301A
  2. Resource Description
    Human FPR1 with Y301A point mutation. Point mutations of human FPR1 cDNA clone R-26 were generated by oligonucleotide-directed mutagenesis and confirmed by DNA sequencing.
  3. Additional Name
    fMet-Leu-Phe receptor; Formyl peptide receptor 1
  4. Contact
    Miettinen, Heini
  5. Construct Backbone
    pBGSA
  6. Accession Number
    M60627
  7. Related Publication or Documentation
    Identification of putative sites of interaction between the human formyl peptide receptor and G protein.
  8. Related Publication or Documentation
    A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activation and chemotaxis.
  9. Selectable Marker
    G418
  10. Related Technique
    Transfection
  11. Location
    Miettinen Lab
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    tjohnson
  3. created
    2011-07-06T12:55:05.587-05:00
  4. creator
    qking (Quinton King)
  5. modified
    2016-08-25T15:20:52.059-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016