FPR1 Y301A

eagle-i ID

Resource Type

Properties

1. Construct Insert

   FPR1 Y301A

2. Resource Description

   Human FPR1 with Y301A point mutation. Point mutations of human FPR1 cDNA clone R-26 were generated by oligonucleotide-directed mutagenesis and confirmed by DNA sequencing.

3. Additional Name

   fMet-Leu-Phe receptor; Formyl peptide receptor 1

4. Contact

   Miettinen, Heini

5. Construct Backbone

   pBGSA

6. Accession Number

   M60627

7. Related Publication or Documentation

   Identification of putative sites of interaction between the human formyl peptide receptor and G protein.

8. Related Publication or Documentation

   A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activation and chemotaxis.

9. Selectable Marker

   G418

10. Related Technique

    Transfection

11. Location

    Miettinen Lab