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Voyich-Kane Lab

Summary:

The long-term objective of our research is to define the influence of sensory/regulatory systems on Staphylococcus aureus (S. aureus) virulence using clinically relevant strains. Relatively little is known about how pathogens detect components of the human innate immune system to respond and survive within the host. National Institutes of Health (NIH) funded projects in our laboratory investigate molecular mechanisms used by S. aureus to avert destruction by the human innate immune system at the host-pathogen interface during bacteremia and skin infections. Additional NIH funded projects include investigating the characteristics and incidence of methicillin-resistant S. aureus nasal colonization in minority populations. Our lab is also funded by the United States Department of Agriculture (USDA). For our USDA projects we investigate incidence and characteristics of S. aureus in Montana’s dairy herds and study the antimicrobial potential of a chemokine found in bovine milk. We have also started to determine the zoonotic potential of S. aureus and are focusing on the incidence and transmission potential of S. aureus in Montana’s equine populations.

Affiliations:

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Instruments

Organisms and Viruses

  • USA300∆hla ( Staphylococcus aureus )

    Deletion of the Hla toxin from PFGE type USA300. Gene USA300_1058 replaced with spectinomycin cassette.

  • USA300∆lukA/B ( Staphylococcus aureus )

    Deletion of the LukA/B two component leukotoxin from PFGE type USA300. Genes USA300_1974 and USA300_1975 replaced with a spectinomycin cassette.

  • USA300∆saeR/S ( Staphylococcus aureus )

    Deletion of the saeR and saeS genes from PFGE type USA300. Genes USA300_0691 and USA300_0690 replaced with spectinomycin cassette.

  • USA400∆saeR/S ( Staphylococcus aureus )

    Deletion of the saeR and saeS genes from PFGE type USA400. Genes MW0668 and MW0667 replaced with spectinomycin cassette.

Protocols


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Last updated: 2011-04-21T17:50:29.876-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016