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Lei Lab

Summary:

Research in the Lei Lab focuses on pathogenic and therapeutic studies relating to the bacterial pathogens Streptococcus pyogenes and Streptococcus equi.

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Organisms and Viruses

  • MGAS2221 ∆sse ( Streptococcaceae )

    Deletion mutant of the esterase SsE gene in Group A Streptococcus serotype M1 strain MGAS2221.

  • MGAS315 ∆sagA ( Streptococcaceae )

    Deletion mutant of the sagA gene in Group A Streptococcus serotype M3 strain MGAS315.

  • MGAS315 ∆scpA ( Streptococcaceae )

    Deletion mutant of the C5a peptidase ScpA gene in Group A Streptococcus serotype M3 strain MGAS5005.

  • MGAS315 ∆slo ( Streptococcaceae )

    Deletion mutant of the streptolysin O gene in Group A Streptococcus serotype M3 strain MGAS315.

  • MGAS315 ∆spyCEP ( Streptococcaceae )

    Deletion mutant of the IL-8 peptidase gene in Group A Streptococcus serotype M3 strain MGAS315.

  • MGAS315 ∆spyCEP∆scpA ( Streptococcaceae )

    Double deletion mutant of the IL-8 peptidase SpyCEP and C5a peptidase genes in Group A Streptococcus serotype M3 strain MGAS315.

  • MGAS315 ∆spyCEP∆sse ( Streptococcaceae )

    Double deletion mutant of the IL-8 peptidase SpyCEP and esterase SsE genes in Group A Streptococcus serotype M3 strain MGAS315.

  • MGAS315 ∆sse ( Streptococcaceae )

    Deletion mutant of the esterase SsE gene in Group A Streptococcus serotype M3 strain MGAS315.

  • MGAS315 ∆sse∆sagA ( Streptococcaceae )

    Double deletion mutant of the esterase SsE gene and SagA gene in Group A Streptococcus serotype M3 strain MGAS315.

  • MGAS315 ∆sse∆sagA∆slo ( Streptococcaceae )

    Triple deletion mutant of the esterase SsE, sagA and streptolysin O genes in Group A Streptococcus serotype M3 strain MGAS315.

  • MGAS315 ∆sse∆scpA ( Streptococcaceae )

    Double deletion mutant of the esterase SsE and C5a peptidase ScpA genes in Group A Streptococcus serotype M3 strain MGAS315.

  • MGAS315 ∆sse∆scpA∆spyCEP ( Streptococcaceae )

    Triple deletion mutant of the esterase SsE, C5a peptidase ScpA and IL-8 peptidase SpyCEP genes in Group A Streptococcus serotype M3 strain MGAS315.

  • MGAS315 ∆sse∆scpA∆spyCEP∆slo ( Streptococcaceae )

    Quadruple deletion mutant of the esterase SsE, C5a peptidase ScpA, IL-8 peptidase SpyCEP and streptolysin O genes in Group A Streptococcus serotype M3 strain MGAS315.

  • MGAS315 ∆sse∆scpA∆spyCEP∆slo∆sagA ( Streptococcaceae )

    Quintuple deletion mutant of the esterase SsE, C5a peptidase ScpA, IL-8 peptidase SpyCEP, streptolysin O and SagA genes in Group A Streptococcus serotype M3 strain MGAS315.

  • MGAS315 ∆sse∆slo ( Streptococcaceae )

    Double deletion mutant of the esterase SsE and streptolysin O genes in Group A Streptococcus serotype M3 strain MGAS315.

  • MGAS5005 vicR- ( Streptococcus pyogenes )

    Insertional mutant of the vicR gene of the two component regulatory system VicRK in Group A Streptococcus serotype M1 strain MGAS5005.

  • MGAS5005 ∆ftsB ( Streptococcus pyogenes )

    Deletion mutant of the ftsB gene, the lipoprotein gene of the ferric ferrichrome transporter FtsABCD in MGAS5005.

  • MGAS5005 ∆ftsC ( Streptococcus pyogenes )

    Deletion mutant of the ftsC gene, the permease gene of the ferric ferrichrome transporter FtsABCD in MGAS5005.

  • MGAS5005 ∆mtsR ( Streptococcus pyogenes )

    Deletion mutant of the metalloregulator mtsR gene in MGAS5005.

  • MGAS5005 ∆scpA ( Streptococcaceae )

    Deletion mutant of the C5a peptidase gene in Group A Streptococcus serotype M1 strain MGAS5005.

  • MGAS5005 ∆spyCEP ( Streptococcaceae )

    Deletion mutant of the IL-8 peptidase SpyCEP gene in group A Streptococcus strain MGAS5005.

  • MGAS5005 ∆spyCEP∆scpA ( Streptococcaceae )

    Double deletion mutant of the IL-8 peptidase SpyCEP and C5a peptidase ScpA genes in Group A Streptococcus M1 strain MGAS5005.

  • MGAS5005 ∆spyCEP∆scpA∆sse: ( Streptococcaceae )

    Triple deletion mutant of the IL-8 peptidase SpyCEP, C5a peptidase ScpA and esterase SsE genes in Group A Streptococcus strain MGAS5005.

  • MGAS5005 ∆spyCEP∆sse ( Streptococcaceae )

    Double deletion mutant of the IL-8 peptidase SpyCEP and esterase SsE genes in Group A Streptococcus serotype M1 strain MGAS5005.

  • MGAS5005 ∆sse ( Streptococcus pyogenes )

    Esterase deletion mutant of Group A Streptococcus serotype M1 strain MGAS5005.

  • MGAS5005 ∆sse∆scpA ( Streptococcaceae )

    Double deletion mutant of the esterase SsE and C5a peptidase ScpA genes in Group A Streptococcus strain MGAS5005.

  • MGAS5005 ∆vicK ( Streptococcus pyogenes )

    Deletion mutant of the vicK gene, the sensor vicK gene of the two component regulatory system VicRK in MGAS5005.

  • NY06520 ∆sse ( Streptococcaceae )

    Deletion mutant of the esterase SsE gene in Group A Streptococcus serotype M12 strain NY06520.

  • Streptococcus equi ∆vicK ( Streptococcus equi )

    Deletion mutant of the vicK gene, the sensor gene of the two component regulatory system VicRK in Streptococcus equi.

Reagents

  • pISDA ( Prokaryotic expression construct )

    The gene clone of the IsdA gene of Staphylococcus aureus. This gene encodes a protein involved in heme acquisition in S. aureus.

  • pISDC ( Prokaryotic expression construct )

    The gene clone of the IsdC gene of Staphylococcus aureus. This gene encodes a protein involved in heme acquisition in S. aureus.

  • pISDE ( Prokaryotic expression construct )

    The gene clone of the IsdE gene of Staphylococcus aureus. This gene encodes a protein involved in heme acquisition in S. aureus.


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Last updated: 2011-07-01T15:37:38.419-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016