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Quinn Lab

Summary:

The long-term goal of my research program is to understand the molecular basis of leukocyte superoxide (O2-) production and the role of leukocyte-generated oxidants in the tissue damage associated with inflammatory diseases in animals. Because of the importance of leukocytes in host defense and in inflammatory diseases, the research in my lab is focused on four primary approaches to understanding the biochemistry and molecular biology of the NADPH oxidase and the role of leukocyte-derived oxidants in tissue injury. These approaches include: 1) analysis of the human and bovine neutrophil NADPH oxidase to determine the protein and lipid components involved and how these components assemble with each other at the molecular level; 2) biochemical and molecular biological analysis of the proteins known to be involved in the NADPH oxidase to determine their molecular structure and functional role in enzymatic activity; 3) functional analysis of the NADPH oxidase to determine how this system is regulated and what causes this system to become deregulated during disease states; and 4) analysis of inflamed tissues for markers of oxidant injury.

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Last updated: 2011-04-22T16:07:08.745-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016