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Schmidt Lab

Summary:

The lab's primary research interests are to understand the intricate gene regulatory mechanisms that function in development and maintenance of complex organisms, like ourselves.

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Organisms and Viruses

  • TBP-∆N ( Mus musculus )

    Locus: tbp
    Allelic designation: tbp[∆N]
    Homozygous condition: tbp[∆N/∆N]
    mRNA designation: TBP∆N mRNA
    Protein designation: TBP∆N
    Origin: Developed on a 129XI ES cell background and backcrossed >20 generations onto C57Bl/6J

    Status: Active. This colony has endemic MNV, which we are in the process of eliminating.

    Related disease: Congenital, Hereditary, and Neonatal Diseases and Abnormalities

    Availability: Heterozygotes of either sex are freely available for unrestricted non-profit research use by qualified programs/institutions. Recipient will pay per diem for production of one liter and will cover costs for health reports and shipping.

  • Thioredoxin reductase 1 - Conditional Null ( Mus musculus )

    Locus: txnrd1
    Allelic designation: txnrd1[cond]
    Homozygous condition: txnrd1[cond/cond]
    mRNA designation: Txnrd1 mRNA (also called TrxR1 mRNA, Tr1 mRNA)
    Protein designation: Txnrd1 (also called TrxR1, Tr1)

    Origin: Developed on a 129XI ES cell background and backcrossed > 10 generations onto C57Bl/6J. The purely backcrossed line was lost during elimination of MNV from the colony and the line was recovered from individuals that had some ancestors with less defined strain backgrounds (JAX stock #s 007576, 004847, and 003574). These are being continuously backcrossed onto C57Bl/6J.

    Status: Active. MNV-free.

    Related disease: Congenital, Hereditary, and Neonatal Diseases and Abnormalities

    Availability: Heterozygotes of either sex are freely available for unrestricted non-profit research use by qualified programs/institutions. Recipient will pay per diem for production of one liter and will cover costs for health reports and shipping.

  • Thioredoxin Reductase 1 - Null ( Mus musculus )

    Locus: txnrd1
    Allelic designation: txnrd1[null] (or txnrd1- )
    Homozygous condition: txnrd1[null/null] (or txnrd1[-/-] )
    mRNA designation: Txnrd1- null mRNA
    Protein designation: (no protein encoded by this allele)

    Origin: Developed on a 129XI ES cell background and backcrossed > 10 generations onto C57Bl/6J. The purely backcrossed line was lost during elimination of MNV from the colony and the line was recovered from individuals that had some ancestors with less defined strain backgrounds (JAX stock #s 007576, 004847, and 003574). These are being continuously backcrossed onto C57Bl/6J.

    Status: Active. MNV-free.

    Related disease: Congenital, Hereditary, and Neonatal Diseases and Abnormalities

    Availability: Heterozygotes of either sex are freely available for unrestricted non-profit research use by qualified programs/institutions. Recipient will pay per diem for production of one liter and will cover costs for health reports and shipping.


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Last updated: 2011-04-29T13:49:15.979-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016