The primary goal of our research is to contribute to a better understanding of why the hippocampus is sensitive to transient cerebral ischemia. During transient cerebral ischemia, intracellular calcium increases initiating a cascade of events which leads to the delayed death of neurons located in the hippocampus.
Our research group is studying the role of calcium targets in mediating hippocampal damage. Behavioral deficits associated with cerebral ischemia in animal models provide a useful tool for understanding the role hippocampus in learning and memory.
Our laboratory uses a variety of behavioral paradigms in conjunction with traditional neuroscience techniques to study how ischemic insult damages the brain.