The NIH Center of Biomedical Research Excellence (COBRE) for Structural and Functional Neuroscience at The University of Montana was established through the Institutional Development Award program of the National Center for Research Resources. The research mission of the Center is to utilize approaches at the interface of molecular pharmacology, synthetic chemistry, physiology, and molecular biology to advance our understanding of the central nervous system, particularly as related to protein structure and function, signaling, transport, and pathogenesis. The Center is also intended to serve as a core around which to develop infrastructure that benefits a much broader range of basic, clinical and translational biomedical research efforts in Montana. The Center is directed by Michael Kavanaugh, Ph.D., and Center investigators include faculty from departments including Biomedical and Pharmaceutical Sciences, Chemistry, Mathematics, and the Division of Biological Sciences at The University of Montana-Missoula. In addition to the Missoula campus, Center investigators are also located at the McLaughlin Research Institute in Great Falls and at Montana State University. CSFN is Supported by NIH Grant Number P20 RR015583 from the COBRE Program of the National Center for Research Resources.